Bjur K A, Jacobson R M
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905-0001, USA.
Minerva Pediatr. 2009 Oct;61(5):515-21.
Rotavirus is the leading cause of severe, dehydrating diarrhea worldwide and is responsible for more than 600 000 child deaths every year. In June 2009, the World Health Organization recommended inclusion of rotavirus vaccination in all national immunization programs. This universal endorsement of rotavirus vaccination should help the world's poorest countries to provide rotavirus vaccine to the poorest children, in order to achieve the Millennium Development Goal #4 of decreasing child mortality by two-thirds by 2015. This review will focus on the nature and epidemiology of the virus and on the history of rotavirus vaccine, its availability and current recommendations about its administration.
轮状病毒是全球严重脱水腹泻的主要病因，每年导致60多万儿童死亡。2009年6月，世界卫生组织建议将轮状病毒疫苗纳入所有国家免疫规划。对轮状病毒疫苗的这一普遍认可应有助于世界上最贫穷的国家为最贫困儿童提供轮状病毒疫苗，以实现到2015年将儿童死亡率降低三分之二的千年发展目标4。本综述将重点关注该病毒的性质和流行病学、轮状病毒疫苗的历史、其可及性以及目前关于其接种的建议。
