Anashkina L M
Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(7):90-4.
The clinico-epidemiological method was used to examine the patients' population suffering from attack-like schizophrenia with a disease standing of 25 and more years. There were altogether 245 persons. Depressive attacks of the endogenous type were revealed in 1/3 of the patients, amounting to 153 attacks in total. Of these, 76.5% occurred at the disease onset, namely from the first to the fifth attack. A comparative all-round study was made of the efficacy of neuroleptics, antidepressants and combined therapy of neuroleptics and antidepressants, insulin coma ++ therapy and symptomatic remedies bearing in mind such criteria as the rate of attack removal, remission duration and quality, the character of the maintenance therapy. It has been established that the use of psychopharmacotherapy removes a depressive attack of the endogenous type more swiftly but long and stable remissions are only ensured by antidepressants.
采用临床流行病学方法对病程达25年及以上的发作样精神分裂症患者群体进行研究。患者共计245人。1/3的患者出现内源性抑郁发作，总共153次发作。其中，76.5%发生在疾病发作时，即从首次发作到第五次发作期间。对神经阻滞剂、抗抑郁药以及神经阻滞剂与抗抑郁药联合治疗、胰岛素昏迷++疗法和对症治疗的疗效进行了全面比较研究，考量的标准包括发作消除率、缓解持续时间和质量、维持治疗的特点等。结果表明，使用精神药物疗法能更快消除内源性抑郁发作，但只有抗抑郁药才能确保长期稳定的缓解。
