[Comparative effectiveness of various methods of the treatment of patients with attack-like schizophrenia with depressive episodes].

The clinico-epidemiological method was used to examine the patients' population suffering from attack-like schizophrenia with a disease standing of 25 and more years. There were altogether 245 persons. Depressive attacks of the endogenous type were revealed in 1/3 of the patients, amounting to 153 attacks in total. Of these, 76.5% occurred at the disease onset, namely from the first to the fifth attack. A comparative all-round study was made of the efficacy of neuroleptics, antidepressants and combined therapy of neuroleptics and antidepressants, insulin coma ++ therapy and symptomatic remedies bearing in mind such criteria as the rate of attack removal, remission duration and quality, the character of the maintenance therapy. It has been established that the use of psychopharmacotherapy removes a depressive attack of the endogenous type more swiftly but long and stable remissions are only ensured by antidepressants.