[Modified insulin treatment of therapy refractory depression].

In the light of progress in psychiatric therapy the problem of treatment-resistance deserves increasing attention. One of the most important challenges in modern psychiatry is to further reduce treatment failure. In so-called treatment-resistant depression various strategies are recommended. In the present paper a regimen is described that only little attention is paid to: Subliminal induced-hypoglycemia (insulin therapy), that coursed amelioration in about 3/4 of the patients.