Pirrotta V
Department of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston 77030.
Bioessays. 1990 Sep;12(9):409-14. doi: 10.1002/bies.950120903.
Numerous genes contain regulatory elements located many tens of kilobases away from the promoter they control. Specific mechanisms must be required to ensure that such distant elements can find and interact with their proper targets but not with extraneous genes. This review explores the connections between transvection phenomena, the activation of domains of homeotic gene expression, position effect variegation and silencers. These various examples of long-distance effects suggest that, in all cases, related forms of chromatin packaging may be involved.
许多基因包含的调控元件距离它们所控制的启动子有数十千碱基之远。必然需要特定的机制来确保这些远距离元件能够找到并与其合适的靶标相互作用，而不与无关基因相互作用。本综述探讨了异位效应现象、同源异型基因表达结构域的激活、位置效应斑驳和沉默子之间的联系。这些远距离效应的各种实例表明，在所有情况下，可能都涉及相关形式的染色质包装。
