Department of Electrical and Computer Engineering, Texas A&M University, Computational Biology Division, Translational Genomics Research Institute, USA.
Curr Genomics. 2009 Apr;10(2):102-9. doi: 10.2174/138920209787847005.
The term "translational science" has recently become very popular with its usage appearing to be almost exclusively related to medicine, in particular, the "translation" of biological knowledge into medical practice. Taking the perspective that translational science is somehow different than science and that sound science is grounded in an epistemology developed over millennia, it seems imperative that the meaning of translational science be carefully examined, especially how the scientific epistemology manifests itself in translational science. This paper examines epistemological issues relating mainly to modeling in translational science, with a focus on optimal operator synthesis. It goes on to discuss the implications of epistemology on the nature of collaborations conducive to the translational investigative process. The philosophical concepts are illustrated by considering intervention in gene regulatory networks.
“转化科学”一词最近变得非常流行，其使用似乎几乎完全与医学相关，特别是将生物学知识“转化”为医学实践。从转化科学在某种程度上不同于科学，而健全的科学是建立在几千年发展起来的认识论的观点出发，似乎有必要仔细检查转化科学的含义，特别是科学认识论在转化科学中的表现。本文主要探讨了转化科学中的建模所涉及的认识论问题，重点是最优算子综合。接着讨论了认识论对促进转化研究过程的合作性质的影响。通过考虑基因调控网络中的干预，来说明哲学概念。
