磷酸化酶激酶亚基中存在的有害序列。
Pest sequences present in the subunits of phosphorylase kinase.
作者信息
Sotiroudis T G, Xenakis A
机构信息
Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece.
出版信息
Biochem Int. 1990 Aug;21(5):941-7.
We report that the amino acid sequences of all four subunits of rabbit skeletal muscle phosphorylase kinase possess one or more regions rich in proline (P), glutamic acid (E), serine (S) and threonine (T). alpha and beta subunits contain strong PEST sequences, showing PEST scores greater than 0 (Rogers et al. (1986) Science 234, 364-368), while gamma and delta subunits contain weak PEST regions (negative PEST scores greater than -5.3). In addition to PEST sequences, alpha, beta and gamma subunits contain clusters of arginine pairs. The above sequence characteristics may serve to signal rapid turnover of phosphorylase kinase.
我们报告称，兔骨骼肌磷酸化酶激酶的所有四个亚基的氨基酸序列都拥有一个或多个富含脯氨酸（P）、谷氨酸（E）、丝氨酸（S）和苏氨酸（T）的区域。α和β亚基含有较强的PEST序列，其PEST得分大于0（Rogers等人，（1986年）《科学》234卷，364 - 368页），而γ和δ亚基含有较弱的PEST区域（负PEST得分大于 - 5.3）。除了PEST序列外，α、β和γ亚基还含有精氨酸对簇。上述序列特征可能有助于表明磷酸化酶激酶的快速周转。
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