Department of Urology, Akdeniz University, Faculty of Medicine, Antalya, Turkey.
J Korean Med Sci. 2009 Oct;24(5):849-52. doi: 10.3346/jkms.2009.24.5.849. Epub 2009 Sep 23.
Unilateral obstruction or injury to the vas deferens can result in significant injury to the contralateral testicle. Although various pathways have been proposed, the mechanism of contralateral testicular deterioration remains controversial. The present animal study was performed to evaluate the effects of unilateral vasectomy on ipsilateral and contralateral testicular histology and fertility in rats that were chemically sympathectomized neonatally. The study comprised 40 male albino rats: 20 received a placebo and the other 20 underwent chemical sympathectomy neonatally. When 60 days old, each group of 20 rats was divided into two groups that underwent either a sham operation or an operation to create unilateral left vasectomy. Eight weeks after surgery, each male rat was housed with two known fertile female rats for 25 days, and then their testes were harvested. Mean seminiferous tubular diameters (MSTD) and mean testicular biopsy scores (MTBS) were determined for each testis. Although MSTD and MTBS were not significantly different between groups, chemical sympathectomy prevented the decrease in total fertility rates of the rats with unilateral left vasectomy in our study. Prevention of this decrease by chemical sympathectomy suggests that the sympathetic nervous system may play a role in the testicular degeneration associated with vasectomy.
单侧输精管阻塞或损伤可导致对侧睾丸的严重损伤。尽管已经提出了各种途径，但对侧睾丸恶化的机制仍存在争议。本动物研究旨在评估新生化学交感神经切断术对大鼠单侧输精管结扎术对同侧和对侧睾丸组织学和生育力的影响。该研究包括 40 只雄性白化大鼠：20 只接受安慰剂，另外 20 只接受新生化学交感神经切断术。当它们 60 天大时，每组 20 只大鼠又分为两组，分别进行假手术或左侧单侧输精管结扎术。手术后 8 周，每只雄性大鼠与两只已知有生育能力的雌性大鼠一起饲养 25 天，然后采集它们的睾丸。每个睾丸的平均生精小管直径（MSTD）和平均睾丸活检评分（MTBS）。尽管 MSTD 和 MTBS 在各组之间无显著差异，但本研究中的化学交感神经切断术可预防单侧左侧输精管结扎大鼠的总生育率下降。化学交感神经切断术的这种预防作用表明，交感神经系统可能在与输精管结扎术相关的睾丸退化中发挥作用。
