Parsons, South Jordan, Utah 84095, USA.
Bull Environ Contam Toxicol. 2010 Jan;84(1):76-9. doi: 10.1007/s00128-009-9882-6. Epub 2009 Oct 1.
In fish, selenium can bioaccumulate and cause adverse impacts. One of the fish species potentially at risk from selenium in the San Francisco Bay (California, USA) is the splittail (Pogonichthys macrolepidotus). Previous studies have derived a whole body NOAEL and LOAEL of 9.0 and 12.9 mg/kg-dw, respectively, for selenium in juveniles. However, the NOAEL/LOAEL approach leaves some uncertainty regarding the threshold of toxicity. Therefore, the raw data from the original experiment was re-analyzed using a logistic regression to derive EC(10) values of 0.9 mg/kg-dw in feed, 7.9 mg/kg-dw in muscle, 18.6 mg/kg-dw in liver for juvenile splittail. Selenium concentrations in the dietary items of wild splittail exceed the EC(10) values derived here. Thus, deformities previously reported in wild splittail may have resulted from selenium exposures via the food chain.
在鱼类中，硒可以生物积累并造成不良影响。在旧金山湾（美国加利福尼亚州），一种可能受到硒影响的鱼类是小口拟石首鱼（Pogonichthys macrolepidotus）。先前的研究已经得出了幼鱼硒的全身无观察不良反应水平（NOAEL）和观察到不良反应水平（LOAEL）分别为 9.0 和 12.9 mg/kg-dw。然而，NOAEL/LOAEL 方法在毒性阈值方面仍存在一些不确定性。因此，使用逻辑回归对原始实验的原始数据进行了重新分析，得出了幼鱼大口拟石首鱼在饲料中的 EC(10)值为 0.9 mg/kg-dw，肌肉中的 EC(10)值为 7.9 mg/kg-dw，肝脏中的 EC(10)值为 18.6 mg/kg-dw。野生大口拟石首鱼的饮食中硒的浓度超过了这里得出的 EC(10)值。因此，以前在野生大口拟石首鱼中报告的畸形可能是由于食物链中的硒暴露造成的。
