环肽：具有药物设计和农业应用的大环肽。
Cyclotides: macrocyclic peptides with applications in drug design and agriculture.
机构信息
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
出版信息
Cell Mol Life Sci. 2010 Jan;67(1):9-16. doi: 10.1007/s00018-009-0159-3. Epub 2009 Oct 1.
Abstract
Cyclotides are disulfide-rich peptides from plants that are exceptionally stable as a result of their unique cyclic cystine knot structural motif. Their natural role is thought to be as plant defence agents, most notably against insect pests, but they also have potential applications in drug design and agriculture. This article identifies gaps in current knowledge on cyclotides and suggests future directions for research into this fascinating family of ultra-stable mini-proteins.
摘要
环肽是一类富含二硫键的植物肽，由于其独特的环半胱氨酸结结构基序，具有异常的稳定性。它们的自然作用被认为是作为植物防御剂，最显著的是对抗昆虫害虫，但它们也有可能在药物设计和农业方面得到应用。本文确定了目前对环肽认识上的差距，并为这一迷人的超稳定小蛋白家族的研究提出了未来的方向。
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本文引用的文献
1
Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes.尽管存在保守的胱氨酸结基序，但不同的环肽具有不同的膜结合模式。
Biophys J. 2009 Sep 2;97(5):1471-81. doi: 10.1016/j.bpj.2009.06.032.
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The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores.原型环肽kalata b1的生物活性受多聚体孔形成的调节。
J Biol Chem. 2009 Jul 31;284(31):20699-707. doi: 10.1074/jbc.M109.003384. Epub 2009 Jun 1.
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Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides.来自蜜囊花科植物（Violaceae）的环状蛋白完善了环肽的保守蛋白和基因结构。
Org Biomol Chem. 2009 Jun 7;7(11):2378-88. doi: 10.1039/b823020j. Epub 2009 Apr 6.
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Circling the enemy: cyclic proteins in plant defence.环绕敌人：植物防御中的环状蛋白
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Total chemical synthesis of proteins.蛋白质的全化学合成
Chem Soc Rev. 2009 Feb;38(2):338-51. doi: 10.1039/b700141j. Epub 2008 Sep 16.
6
Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity.从金属积累植物宝华堇菜中鉴定出两套环肽前体基因：cDNA序列变异、可变RNA剪接及潜在的环肽多样性
Gene. 2009 Feb 15;431(1-2):23-32. doi: 10.1016/j.gene.2008.11.005. Epub 2008 Nov 19.
7
Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms.环肽的驱虫活性：对犬钩虫和人钩虫的体外研究
Acta Trop. 2009 Feb;109(2):163-6. doi: 10.1016/j.actatropica.2008.11.003. Epub 2008 Nov 18.
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Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides.工程化稳定的血管内皮生长因子-A拮抗剂：环肽嫁接类似物的合成、结构表征及生物活性
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Cyclic peptides from Oldenlandia affinis DC. Molecular and biological properties.来自白花蛇舌草的环肽。分子和生物学特性。
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Distribution and evolution of circular miniproteins in flowering plants.环状微蛋白在开花植物中的分布与进化
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