Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina.
Acta Physiol (Oxf). 2010 Mar;198(3):355-60. doi: 10.1111/j.1748-1716.2009.02049.x. Epub 2009 Oct 1.
Appropriate nutritional and vigilance states are needed for reproduction. In previous works, we described the influence of the hormonal milieu of proestrus on the orexinergic system and we found that orexin receptor 1 expression in the hypothalamus, but not other neural areas, and the adenohypophysis was under the influence of oestradiol and the time of the day. Information from the sexual hormonal milieu of proestrous afternoon impacts on various components of the orexinergic system and alertness on this particular night of proestrus would be of importance for successful reproduction. In this review, we summarize the available experimental data supporting the participation of orexins in the hypothalamic-pituitary-ovarian relationships. All together, these results suggest a role of the orexinergic system as an integrative link among vital functions such as reproduction, food intake, alertness and the inner biological clock.
适当的营养和警觉状态是繁殖所必需的。在之前的工作中，我们描述了发情前期激素环境对食欲素系统的影响，我们发现下丘脑而不是其他神经区域的食欲素受体 1 表达和腺垂体受到雌激素和时间的影响。来自发情前期下午性荷尔蒙环境的信息会影响食欲素系统的各个组成部分，而发情前期这个特殊夜晚的警觉性对于成功繁殖至关重要。在这篇综述中，我们总结了支持食欲素参与下丘脑-垂体-卵巢关系的现有实验数据。总之，这些结果表明，食欲素系统作为生殖、食物摄入、警觉性和内部生物钟等重要功能之间的整合环节发挥作用。
