Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan.
Cell Signal. 2010 Feb;22(2):175-82. doi: 10.1016/j.cellsig.2009.09.036. Epub 2009 Sep 30.
Dock180-related proteins are genetically conserved from Drosophila and C. elegans to mammals and are atypical types of guanine-nucleotide exchange factors (GEFs) for Rac and/or Cdc42 of small GTPases of the Rho family. Eleven members of the family occur in mammalian cells, each playing key roles in many aspects of essential cellular functions such as regulation of cytoskeletal organization, phagocytosis, cell migration, polarity formation, and differentiation. This review will summarize the newly accumulated findings concerning the Dock180-related proteins' molecular and cellular functions, emphasizing the roles of these proteins in neuronal cells and glial cells as well as their interactions in the central and peripheral nervous systems.
Dock180 相关蛋白在从果蝇和秀丽隐杆线虫到哺乳动物的物种中具有遗传保守性，是 Rac 和/或 Rho 家族小 GTPase 的 Cdc42 的非典型鸟嘌呤核苷酸交换因子（GEFs）。该家族的 11 个成员存在于哺乳动物细胞中，每个成员在细胞骨架组织调节、吞噬作用、细胞迁移、极性形成和分化等重要细胞功能的多个方面发挥关键作用。本综述将总结有关 Dock180 相关蛋白的分子和细胞功能的新积累的发现，强调这些蛋白在神经元细胞和神经胶质细胞中的作用以及它们在中枢和外周神经系统中的相互作用。
