Reich Nancy C
Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.
Sci Signal. 2009 Sep 29;2(90):pe61. doi: 10.1126/scisignal.290pe61.
Tyrosine phosphorylation of signal transducers and activators of transcription (STATs) promotes their dimerization and ability to bind target genes in the nucleus. However, evidence shows that one member of the STAT family, STAT3, has an additional property independent of its classical role in the nucleus. STAT3 modifed by serine phosphorylation augmented oxidative phosphorylation in mitochondria and supported cellular transformation by oncogenic Ras.
信号转导子和转录激活子（STATs）的酪氨酸磷酸化促进其在细胞核内二聚化并与靶基因结合的能力。然而，有证据表明，STAT家族的一个成员STAT3具有一种独立于其在细胞核中的经典作用的额外特性。经丝氨酸磷酸化修饰的STAT3增强了线粒体中的氧化磷酸化，并通过致癌性Ras支持细胞转化。
