采用 25 微克米索前列醇阴道胶囊进行引产。
Labor induction with 25-microg misoprostol vaginal capsules.
机构信息
Department of Obstetrics, Gynecology and Reproductive Medicine, Hospital Santa Maria, Lisbon, Portugal.
出版信息
Gynecol Obstet Invest. 2009;68(4):272-5. doi: 10.1159/000242427. Epub 2009 Sep 30.
AIM
To evaluate the success rate and the safety profile of labor induction with a new misoprostol formulation - vaginal capsules of 25 microg of misoprostol.
METHODS
Labor induction was performed in 250 singleton term pregnancies; 149 (59.6%) were nulliparous. Vaginal capsules of 25 microg of misoprostol were placed in the posterior vaginal fornix every 6 h. Success rate, contractility and fetal heart rate abnormalities and fetal outcomes were evaluated.
RESULTS
The success rate of labor induction was 97.6%. The average number of vaginal administrations was 1.5. The mean interval between induction and active labor was 10 h and 20 min and the average length of labor was 15 h and 35 min. The cesarean section rate was 18.8%. There were 15 cases of tachysystole, 3 cases of hypertonus and 1 case of hyperstimulation syndrome. There were no adverse neonatal outcomes.
CONCLUSIONS
This study allowed to conclude that labor induction with vaginal capsules of 25 microg of misoprostol is associated with an excellent success rate and safety profile.
目的
评估一种新的米索前列醇制剂-25μg米索前列醇阴道胶囊用于引产的成功率和安全性。
方法
对 250 例足月单胎妊娠进行引产；其中 149 例（59.6%）为初产妇。将 25μg米索前列醇阴道胶囊每隔 6 小时置于阴道后穹窿。评估引产成功率、子宫收缩力和胎心异常以及胎儿结局。
结果
引产成功率为 97.6%。阴道给药的平均次数为 1.5 次。引产至活跃期的平均时间为 10 小时 20 分钟，产程的平均时间为 15 小时 35 分钟。剖宫产率为 18.8%。有 15 例出现心动过速，3 例出现子宫痉挛，1 例出现过度刺激综合征。新生儿无不良结局。
结论
本研究表明，25μg米索前列醇阴道胶囊引产具有极好的成功率和安全性。
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