Sahay K B, Mehrotra R, Sachdeva U, Banerji A K
Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi.
Neurol Res. 1990 Sep;12(3):176-80. doi: 10.1080/01616412.1990.11739939.
Several experimental studies have been made in the past to try to understand the nature of the fluid-induced changes in the intracranial pressures of the animals by infusing fluid into their craniospinal complex. The objective of the present investigation was to study the changes in the characteristics of the ventricular and epidural pressure-volume curves when a dog was subjected to repeated fluid infusion tests. The animals were subjected to three cycles of infusion tests with a time interval of either 10 min or 2 h between any two successive tests. An infusion test repeated 10 min after the preceding test exhibited a significant change in the characteristics of the ventricular fluid pressure (VFP) response but not in the epidural pressure (EDP) response. However, in the case of an infusion test which was repeated 2 h after the preceding test, it was observed that both the VFP and EDP responses remained the same as those found in the first infusion test.
过去已经进行了几项实验研究，试图通过向动物的颅脊髓复合体中注入液体来了解液体引起的动物颅内压变化的性质。本研究的目的是研究当狗接受重复液体注入测试时，脑室和硬膜外压力-容积曲线特征的变化。动物接受了三个周期的注入测试，任意两次连续测试之间的时间间隔为10分钟或2小时。在前一次测试后10分钟重复进行的注入测试显示，脑室液压力（VFP）反应的特征有显著变化，但硬膜外压力（EDP）反应没有变化。然而，在前一次测试后2小时重复进行注入测试的情况下，观察到VFP和EDP反应与第一次注入测试中的反应相同。
