Sahay K B, Kothiyal K P
Int J Neurosci. 1984 Aug;23(4):301-9. doi: 10.3109/00207458408985581.
The pressure-volume relationship (PVR) in the intracranial cerebrospinal fluid space has been a matter of investigation for quite sometime. The quantitative considerations of the PVR are believed to have important clinical implications, and attempts have been made to study the pressure-volume characteristics associated with a variety of disease states. Efforts have been made by researchers to understand the phenomenon in terms of mechanics. The major drawback has been that almost all researchers have invoked in their analyses, concepts from linear infinitesimal elasticity to explain the intracranial PVR. In this paper we have proposed a more realistic hyperelastic model to explain the observed PVR of the intracranial complex. The proposed model provides a better approximation to the intracranial P-V response than those proposed by previous investigators. The model highlights also the parameters that are relevant to characterise the intracranial tissues.
颅内脑脊液空间中的压力-容积关系（PVR）已经成为相当长时间以来的研究课题。PVR的定量考量被认为具有重要的临床意义，并且已经有人尝试研究与各种疾病状态相关的压力-容积特征。研究人员已努力从力学角度理解这一现象。主要的缺点在于，几乎所有研究人员在其分析中都援引了线性无穷小弹性的概念来解释颅内PVR。在本文中，我们提出了一个更符合实际的超弹性模型来解释观察到的颅内复合体的PVR。与先前研究人员提出的模型相比，所提出的模型能更好地近似颅内压力-容积响应。该模型还突出了与表征颅内组织相关的参数。
