Department of Bioengineering, University of Washington, Box 358056, Seattle, WA 98195 USA.
J Cell Commun Signal. 2009 Dec;3(3-4):311-22. doi: 10.1007/s12079-009-0068-0. Epub 2009 Oct 2.
Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety of disease states, including atherosclerosis, glomerulonephritis, cancer, and several chronic inflammatory diseases. Through interactions with several integrins, OPN mediates cell migration, adhesion, and survival in many cell types. OPN also functions as a Th1 cytokine, promotes cell-mediated immune responses, and plays a role in chronic inflammatory and autoimmune diseases. Besides its function in inflammation, OPN is also a regulator of biomineralization and a potent inhibitor of vascular calcification.
骨桥蛋白（OPN）是一种细胞外基质蛋白，具有多种生物学功能。OPN 参与正常的生理过程，并与多种疾病状态的发病机制有关，包括动脉粥样硬化、肾小球肾炎、癌症和几种慢性炎症性疾病。OPN 通过与几种整合素相互作用，介导许多细胞类型中的细胞迁移、黏附和存活。OPN 还作为 Th1 细胞因子发挥作用，促进细胞介导的免疫反应，并在慢性炎症和自身免疫性疾病中发挥作用。除了在炎症中的作用外，OPN 还是生物矿化的调节剂和血管钙化的有效抑制剂。
