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难治性造口旁溃疡:一种多学科方法

Refractory parastomal ulcers: a multidisciplinary approach.

作者信息

Wolfsen H C, Brubacher L L, Ng C S, Kayne A L, Kozarek R A

机构信息

Section of Gastroenterology, Virginia Mason Clinic, Seattle, Washington 98111.

出版信息

J Clin Gastroenterol. 1990 Dec;12(6):651-5. doi: 10.1097/00004836-199012000-00011.

Abstract

Chronic parastomal ulcers in patients with ileostomy or colostomy stomas are unusual. Previous reports have implicated infections, fistulas, recurrent inflammatory bowel disease (IBD), pyoderma gangrenosum, and trauma. Over the past 8 years we have evaluated 10 cases of such refractory parastomal ulcers that occurred at a mean of 11 years after stomal surgery. Eight patients had had an ileostomy for IBD while two had undergone colostomy for colon cancer. Five patients with IBD were diagnosed as having pyoderma gangrenosum ulcerations. They required systemic treatment for a mean of 25 weeks to effect ulcer healing. The other five patients had either parastomal ulcers on the basis of dermatoses (contact dermatitis, eczema, or bullous pemphigoid) or contact ulcers due to face-plate pressure and parastomal dermatitis. These patients received topical treatment with healing of ulcers in a mean of 4 weeks. We conclude that parastomal ulcers occurring in patients without IBD or IBD patients without classic pyoderma gangrenosum require early dermatologic evaluation as they respond relatively quickly to appropriate local therapy.

摘要

回肠造口术或结肠造口术患者出现慢性造口旁溃疡的情况并不常见。既往报道认为其与感染、瘘管、复发性炎症性肠病(IBD)、坏疽性脓皮病和创伤有关。在过去8年中,我们评估了10例这种难治性造口旁溃疡患者,这些溃疡平均在造口手术后11年出现。8例患者因IBD行回肠造口术,2例因结肠癌行结肠造口术。5例IBD患者被诊断为坏疽性脓皮病溃疡。他们平均需要25周的全身治疗才能使溃疡愈合。其他5例患者的造口旁溃疡要么基于皮肤病(接触性皮炎、湿疹或大疱性类天疱疮),要么是由于面板压力和造口旁皮炎导致的接触性溃疡。这些患者接受局部治疗,溃疡平均在4周内愈合。我们得出结论,在无IBD的患者或无典型坏疽性脓皮病的IBD患者中出现的造口旁溃疡需要早期皮肤科评估,因为它们对适当的局部治疗反应相对较快。

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