McGarity W C, Robertson D B, McKeown P P, Amerson J R, Darden W A
Arch Surg. 1984 Oct;119(10):1186-8. doi: 10.1001/archsurg.1984.01390220064014.
Pyoderma gangrenosum is a rare idiopathic skin condition often associated with other diseases, including Crohn's disease. We believe this is the first report of cases in which pyoderma gangrenosum was identified at the parastomal site in patients with Crohn's disease. Four episodes of the condition occurred in three patients. In these patients, pyoderma gangrenosum first appeared after two to three surgical procedures and between ten months and five years after the initial surgery. The disease course varied from resolution within two months with corticosteroid therapy to resolution only after revision or relocation of the stoma with resection of recurrent disease segments. Parastomal pyoderma gangrenosum at the ileostomy site in patients with Crohn's disease may be more common than previously thought. Optimal treatment has not yet been established, and treatment needs to be tailored for each patient.
坏疽性脓皮病是一种罕见的特发性皮肤病，常与包括克罗恩病在内的其他疾病相关。我们认为这是首次报道在克罗恩病患者的造口旁部位发现坏疽性脓皮病的病例。3名患者共出现4次该病发作。在这些患者中，坏疽性脓皮病在两到三次外科手术后首次出现，且在初次手术后10个月至5年之间出现。疾病病程各不相同，有的患者使用皮质类固醇治疗后在两个月内痊愈，有的患者则仅在造口修复或重新定位并切除复发疾病节段后才痊愈。克罗恩病患者回肠造口部位的造口旁坏疽性脓皮病可能比之前认为的更为常见。尚未确定最佳治疗方法，治疗需要针对每位患者进行调整。
