[大鼠肝脏细胞核及核膜在出生后发育和部分肝切除后再生过程中的氧化与磷酸化]
[Oxidation and phosphorylation in rat liver nuclei and nuclear membranes in postnatal development and regeneration after partial hepatectomy].
作者信息
Kalandarishuili F A, Kuz'mina S N, Zbarskii I B
出版信息
Biokhimiia. 1977 Jul;42(7):1167-72.
PMID:198024
Abstract
Specific oxygen consumption by isolated nuclei of liver cells of newborn rats is higher and phosphorylation is lower as compared to adult animals. This is correlated with a higher free cytochrome oxidase activity as determined in the absence of detergents or tetramethyl-p-phenylenediamine. Correspondingly, oxygen consumption by isolated nuclear membranes of rat liver 44 hrs after partial hepatectomy is also increased and the P/O ratio is decreased 2.2-fold as compared to the controls.
摘要
与成年动物相比，新生大鼠肝细胞分离细胞核的特定耗氧量更高，而磷酸化作用更低。这与在没有去污剂或四甲基对苯二胺的情况下测定的较高的游离细胞色素氧化酶活性相关。相应地，部分肝切除术后44小时大鼠肝脏分离核膜的耗氧量也增加，与对照组相比，P/O比值降低了2.2倍。
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