Hallacli Erinc, Akhtar Asifa
Gene Expression Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Chromosome Res. 2009;17(5):603-19. doi: 10.1007/s10577-009-9054-x.
In Drosophila, dosage compensation of the single male X chromosome involves upregulation of expression of X linked genes. Dosage compensation complex or the male specific lethal (MSL) complex is intimately involved in this regulation. The MSL complex members decorate the male X chromosome by binding on hundreds of sites along the X chromosome. Recent genome wide analysis has brought new light into X chromosomal regulation. It is becoming increasingly clear that although the X chromosome achieves male specific regulation via the MSL complex members, a number of general factors also impinge on this regulation. Future studies integrating these aspects promise to shed more light into this epigenetic phenomenon.
在果蝇中，单一雄性X染色体的剂量补偿涉及X连锁基因表达的上调。剂量补偿复合体或雄性特异性致死（MSL）复合体密切参与这一调控过程。MSL复合体成员通过结合在X染色体上的数百个位点来修饰雄性X染色体。最近的全基因组分析为X染色体调控带来了新的认识。越来越清楚的是，尽管X染色体通过MSL复合体成员实现雄性特异性调控，但一些通用因子也对这一调控产生影响。整合这些方面的未来研究有望为这一表观遗传现象带来更多的认识。
