黑腹果蝇的雄性特异性致死基因1（msl-1）编码一种与雄性X染色体相关的新型蛋白质。
The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males.
作者信息
Palmer M J, Mergner V A, Richman R, Manning J E, Kuroda M I, Lucchesi J C
机构信息
Department of Biology, University of North Carolina, Chapel Hill 27599-3280.
出版信息
Genetics. 1993 Jun;134(2):545-57. doi: 10.1093/genetics/134.2.545.
Abstract
Male-specific lethal-one (msl-1) is one of four genes that are required for dosage compensation in Drosophila males. To determine the molecular basis of msl-1 regulation of dosage compensation, we have cloned the gene and characterized its products. The predicted msl-1 protein (MSL-1) has no significant similarity to proteins in the current data bases but contains an acidic N terminus characteristic of proteins involved in transcription and chromatin modeling. We present evidence that the msl-1 protein is associated with hundreds of sites along the length of the X chromosome in male, but not in female, nuclei. Our findings support the hypothesis that msl-1 plays a direct role in increasing the level of X-linked gene transcription in male nuclei.
摘要
雄性特异性致死基因-1（msl-1）是果蝇雄性剂量补偿所需的四个基因之一。为了确定msl-1调控剂量补偿的分子基础，我们克隆了该基因并对其产物进行了表征。预测的msl-1蛋白（MSL-1）与当前数据库中的蛋白质没有明显的相似性，但含有参与转录和染色质建模的蛋白质所特有的酸性N末端。我们提供的证据表明，msl-1蛋白与雄性细胞核中沿X染色体长度的数百个位点相关联，而在雌性细胞核中则不然。我们的研究结果支持了这样一种假设，即msl-1在提高雄性细胞核中X连锁基因转录水平方面发挥直接作用。
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