以安替比林原位吸收作为氟碳代血液稀释大鼠肠血流量的一种测量方法。
The in-situ absorption of antipyrine as a measure of intestinal blood flow in Fluosol-DA haemodiluted rats.
作者信息
Shrewsbury R P, White L G
机构信息
School of Pharmacy, University of North Carolina, Chapel Hill 27599.
出版信息
J Pharm Pharmacol. 1990 Jul;42(7):511-2. doi: 10.1111/j.2042-7158.1990.tb06608.x.
Abstract
The effect of moderate Fluosol-DA haemodilution on intestinal blood flow has been investigated in the rat. Antipyrine in-situ intestinal absorption is blood flow limited, and did not alter 0.5, 24, 48, or 72 h after haemodilution with 40 mL kg-1 Fluosol. Thus the intestinal blood flow rate is maintained as part of the physiological response to ensure adequate perfusion of the vital organ.
摘要
已经在大鼠中研究了适度的氟碳代血液稀释对肠血流量的影响。安替比林的原位肠道吸收受血流限制，在用40 mL/kg氟碳代血液进行血液稀释后0.5、24、48或72小时，其没有改变。因此，肠血流速率作为生理反应的一部分得以维持，以确保重要器官的充分灌注。
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