氟碳乳剂-DA和贺斯血液稀释对大鼠体内S-华法林消除的影响。
The effect of Fluosol-DA and Hespan haemodilution on S-warfarin elimination in the rat.
作者信息
Shrewsbury R P, Hong D D
机构信息
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
出版信息
J Pharm Pharmacol. 1990 Sep;42(9):665-6. doi: 10.1111/j.2042-7158.1990.tb06630.x.
Abstract
Fluosol and Hespan haemodilution in rats did not change S-warfarin elimination within 72 h although previous studies had indicated that Fluosol haemodilution caused an increased cytochrome P450b and P450e activity at 48 h. This study showed that the increased activity at that time was specific for those isoenzymes.
摘要
尽管先前的研究表明氟碳乳剂血液稀释在48小时时会导致细胞色素P450b和P450e活性增加，但在大鼠中进行的氟碳乳剂和贺斯血液稀释在72小时内并未改变S-华法林的消除。这项研究表明，那时活性的增加是这些同工酶所特有的。
Zotero 插件