Husaini J, Choy Y C
Department of Anaesthesiology and Intensive Care, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia.
Med J Malaysia. 2008 Dec;63(5):384-7.
This study to evaluate the relationship between end-tidal carbon dioxide pressure (ETCO2) and arterial partial pressure of carbon dioxide (PaCO2) included 35 patients between the ages of 18 and 65 years, ASA grade 1 and 2, who had elective craniotomies. Measurements of PaCO2 and ETCO2 were taken simultaneously: 1) 10 minutes after induction of general anaesthesia, 2) after cranium opening prior to dural incision, 3) start of dural closure. There was significant correlation between ETCO2 and PaCO2 (correlation coefficient: 0.571, 0.559 and 0.629 respectively). The mean (SD) difference for PaCO2 and ETCO2 were: 3.84 (2.13), 4.85 (5.78) and 3.91 (2.33) mmHg respectively. Although there was agreement, the bias is of significant clinical importance. In conclusion, we find that ETCO2 consistently underestimated the value of PaCO2 during craniotomy.
这项旨在评估呼气末二氧化碳分压（ETCO2）与动脉血二氧化碳分压（PaCO2）之间关系的研究纳入了35例年龄在18至65岁之间、美国麻醉医师协会（ASA）分级为1级和2级且接受择期开颅手术的患者。同时进行PaCO2和ETCO2的测量：1）全身麻醉诱导后10分钟；2）颅骨切开后硬脑膜切开前；3）硬脑膜开始缝合时。ETCO2与PaCO2之间存在显著相关性（相关系数分别为0.571、0.559和0.629）。PaCO2和ETCO2的平均（标准差）差值分别为：3.84（2.13）、4.85（5.78）和3.91（2.33）mmHg。尽管存在一致性，但偏差具有显著的临床意义。总之，我们发现在开颅手术期间ETCO2持续低估了PaCO2的值。
