Rapkin Andrea J, McDonald Michelle, Winer Sharon A
David Geffen School of Medicine at UCLA, Department of Obstetrics & Gynecology, 10833 Le Conte Avenue, Los Angeles, CA 90095-1740, USA.
Womens Health (Lond). 2007 Jul;3(4):395-408. doi: 10.2217/17455057.3.4.395.
A combined oral contraceptive pill containing 20 microg of ethinyl estradiol and 3 mg of the progestin drospirenone in a novel dose regimen (24 active pills followed by 4 placebo pills), has demonstrated efficacy for the symptoms of premenstrual dysphoric disorder, a severe form of premenstrual syndrome, with an emphasis on the affective symptoms. Drospirenone has progestagenic, anti-androgenic and anti-aldosterone properties, which differ from earlier generations of progestins, and reducing the hormone pill-free interval allows for better suppression of ovarian steroid production.
一种复方口服避孕药，含有20微克炔雌醇和3毫克孕激素屈螺酮，采用新型剂量方案（24片活性药片后接4片安慰剂药片），已证明对经前烦躁障碍（一种严重形式的经前综合征）的症状有效，尤其对情感症状效果显著。屈螺酮具有孕激素、抗雄激素和抗醛固酮特性，与早期几代孕激素不同，缩短激素无药间隔期可更好地抑制卵巢甾体激素分泌。
