Lapin I P
Laboratory of Psychopharmacology, Bekhterev Psychoneurological Research Institute, Leningrad, USSR.
Biol Psychiatry. 1990 Dec 1;28(11):997-1003. doi: 10.1016/0006-3223(90)90065-a.
Like the anxiogenic drugs caffeine, pentylenetetrazole, and yohimbine, the endogenous neuroactive monoamine beta-phenylethylamine (PEA) is effective in three tests for anxiogens in mice. In a social interaction test it reduced both the number and duration of contacts. In a conflict situation test (a dark-light chamber) it reduced the number of transitions between dark and light compartments. Diazepam, a standard anxiolytic, prevented both effects of PEA. Intracerebroventricular administration of PEA induced generalized clonic seizures which were antagonized by various anxiolytics but not by the tested doses of butyrophenone neuroleptics and standard anticonvulsants effective in other tests for convulsants.
与具有致焦虑作用的药物咖啡因、戊四氮和育亨宾一样，内源性神经活性单胺β-苯乙胺（PEA）在小鼠的三项致焦虑剂测试中均有效。在社交互动测试中，它减少了接触的次数和时长。在冲突情境测试（明暗箱）中，它减少了在暗箱和明箱隔室之间转换的次数。标准抗焦虑药地西泮可预防PEA的这两种作用。脑室内注射PEA会诱发全身性阵挛性惊厥，各种抗焦虑药可拮抗这种惊厥，但测试剂量的丁酰苯类抗精神病药和在其他惊厥测试中有效的标准抗惊厥药却不能。
