Lapin I P, Slepokurov M V
Farmakol Toksikol. 1991 Nov-Dec;54(6):9-11.
One-day isolation of male albino mice of SHR strain significantly increased the level of social behaviour measured by the number and total duration of active contacts (sniffings). A putative endogenous anxiogen beta-phenylethylamine (5-12.5 mg/kg) inhibited the communication like human anxiogens corazole (10 mg/kg) and caffeine (200 mg/kg). Diazepam (1 mg/kg) prevented the action of phenylethylamine, phenibut (10-50 mg/kg) exerted no effect on it. The social isolation test during studying anxiogens and anxiolytics can be performed on mice as previously on rats.
对SHR品系雄性白化小鼠进行一天的隔离，显著提高了通过主动接触（嗅探）的数量和总持续时间衡量的社会行为水平。一种假定的内源性焦虑原β-苯乙胺（5 - 12.5毫克/千克）像人类焦虑原氯氮卓（10毫克/千克）和咖啡因（200毫克/千克）一样抑制交流。地西泮（1毫克/千克）可预防苯乙胺的作用，苯甲酸钠咖啡因（10 - 50毫克/千克）对其无作用。在研究焦虑原和抗焦虑药时，社会隔离试验可以像之前在大鼠身上那样在小鼠身上进行。
