头孢曲嗪和头孢甘氨酸对大鼠空肠中L-亮氨酸吸收的影响。

Effect of cefatrizine and cephaloglycine on L-leucine absorption in rat jejunum.

Mendizabal M V, Idoate I, Larralde J

Departamento de Fisiología y Nutrición, Facultad de Farmacia, Universidad de Navarra, Pamplona, España.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;96(2):317-20. doi: 10.1016/0742-8413(90)90014-z.

Abstract

The oral cephalosporins: cefatrizine and cephaloglycine inhibit the L-leucine absorption in vivo on rat jejunum. 2. This inhibition is dose and time dependent and the effect is irreversible. 3. These antibiotics have a systemic effect on L-leucine absorption. 4. The inhibition of these antibiotics affect only leucine transport, without affecting the diffusion. 5. Cefatrizine and cephaloglycine inhibit the basolateral (Na(+)-K+) ATPase activity in rat jejunum.

摘要

口服头孢菌素：头孢曲嗪和头孢甘氨酸在体内可抑制大鼠空肠对L-亮氨酸的吸收。2. 这种抑制作用具有剂量和时间依赖性，且效果不可逆。3. 这些抗生素对L-亮氨酸的吸收具有全身作用。4. 这些抗生素的抑制作用仅影响亮氨酸转运，而不影响扩散。5. 头孢曲嗪和头孢甘氨酸可抑制大鼠空肠基底外侧（Na(+)-K+）ATP酶活性。