Moreno M J, Pellicer S, Fernández-Otero M P
Department of Physiology and Nutrition, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.
Arch Toxicol. 1996;70(11):767-72. doi: 10.1007/s002040050338.
In vivo intestinal absorption of L-leucine is significantly decreased by the presence of lindane (0.3, 0.2 and 0.1 mM) in perfusion solution (in situ lindane treatment) for 5 min. The inhibitory effect is earlier when lindane concentration is higher, and it is irreversible. There are no changes in D-galactose absorption when lindane (0.3 and 0.2 mM) is perfused for 5 min, but a significant decrease in observed if pesticide is perfused for 10 min at 0.3 mM concentration. Subcutaneous lindane treatment at a dose of 68.76 mumol/kg over 7 days does not alter D-galactose and L-leucine absorption. In situ lindane treatment (0.3, 0.2 and 0.1 mM) induces a significant decrease in basolateral (Na(+)-K(+)-ATPase activity. In contrast, systemic lindane treatment (s.c. injection) at doses of 34.38 and 68.76 mumol/kg over 7 days does not alter this enzyme activity, although a significant decrease is observed in rats injected s.c. with 68.76 mumol/kg lindane over 15 days.
在灌注溶液（原位林丹处理）中存在林丹（0.3、0.2和0.1 mM）5分钟时，L-亮氨酸的体内肠道吸收显著降低。林丹浓度越高，抑制作用出现得越早，且这种抑制作用是不可逆的。当灌注林丹（0.3和0.2 mM）5分钟时，D-半乳糖吸收没有变化，但如果以0.3 mM浓度灌注农药10分钟，则会观察到显著下降。以68.76 μmol/kg的剂量皮下注射林丹，持续7天，不会改变D-半乳糖和L-亮氨酸的吸收。原位林丹处理（0.3、0.2和0.1 mM）会导致基底外侧（Na(+)-K(+)-ATP酶活性显著降低。相比之下，以34.38和68.76 μmol/kg的剂量皮下注射林丹，持续7天，不会改变这种酶的活性，尽管在皮下注射68.76 μmol/kg林丹15天的大鼠中观察到显著下降。
