Boiadzhieva N
Eksp Med Morfol. 1990;29(3):20-6.
Experimental studies were carried out on white male sexual mature healthy rats with induced alloxan diabetes, to clarify the role of dopaminergic system in the regulation of functions of the insular apparatus of the pancreas. The experiments were performed by the following drugs: bromrcripine, levodopa, a combination of revodopa plus carbidopa and haloperidol. Parameters of carbohydrate metabolism were determined in the course of acute and chronic experiments. The results sustained the hypothesis for participation of dopaminergic system in the regulation of production and secretion of insulin and respectively in the control of carbohydrate metabolism. Independent studies were carried out on white rats with alloxan diabetes after combined administration of dopaminergic pharmacological drugs and sulphanylureic preparation (SUP)-glybenclimide. The mechanisms of interaction after the combined administration of the investigated drugs under the conditions of experimental diabetes mellitus were clarified. The obtained results supplement data, in support of the hypothesis for the role of dopamine as a neuromediator in the regulation of the insular apparatus of the pancreas.
对诱发了四氧嘧啶糖尿病的雄性性成熟健康白色大鼠进行了实验研究，以阐明多巴胺能系统在胰腺胰岛装置功能调节中的作用。实验使用了以下药物：溴隐亭、左旋多巴、左旋多巴加卡比多巴的组合以及氟哌啶醇。在急性和慢性实验过程中测定了碳水化合物代谢参数。结果支持了多巴胺能系统参与胰岛素产生和分泌调节以及分别参与碳水化合物代谢控制的假说。对患有四氧嘧啶糖尿病的白色大鼠在联合给予多巴胺能药理药物和磺脲类制剂（SUP）——格列本脲后进行了独立研究。阐明了在实验性糖尿病条件下联合给予所研究药物后的相互作用机制。所获得的结果补充了数据，支持了多巴胺作为神经介质在胰腺胰岛装置调节中作用的假说。
