Shorin Iu P, Seliatitskaia V G, Nepomniashchikh G I, Pal'chikova N A, Khodova R R
Biull Eksp Biol Med. 1984 Aug;98(8):240-2.
During cold adaptation, the rats demonstrate a significant decrease in plasma immunoreactive insulin (IRI), with glucose concentration remaining invariable. Injection of alloxan (170 mg/kg bw) to control rats causes death of 58% of animals. Survived rats show stable hyperglycemia and a considerable fall of plasma IRI. The insular apparatus of the pancreas undergoes considerable destructive changes. Relative density of the endocrine section decreases dramatically. This is conditioned by the reduction of both the number and size of Langerhans islets. Injection of alloxan to animals after cold adaptation results in the death of 28% of rats. Normoglycemia with invariable plasma IRI level was noticed in survived animals. The changes in the endocrine section of the pancreas were less significant in these animals. The relative volume of islets was almost twice as large as that in control animals after alloxan injection.
在冷适应过程中，大鼠血浆免疫反应性胰岛素（IRI）显著降低，而血糖浓度保持不变。给对照大鼠注射四氧嘧啶（170mg/kg体重）导致58%的动物死亡。存活的大鼠表现出稳定的高血糖和血浆IRI显著下降。胰腺的胰岛装置发生了相当大的破坏性变化。内分泌部分的相对密度急剧下降。这是由于朗格汉斯胰岛的数量和大小都减少所致。对冷适应后的动物注射四氧嘧啶，导致28%的大鼠死亡。在存活的动物中观察到血糖正常且血浆IRI水平不变。这些动物胰腺内分泌部分的变化不太明显。胰岛的相对体积几乎是注射四氧嘧啶后对照动物的两倍。
