MSH6 syndrome.
作者信息
Suchy Janina, Lubinski Jan
机构信息
International Hereditary Cancer Centre, Department of Genetics and Pathology, Szczecin, Poland.
出版信息
Hered Cancer Clin Pract. 2008 Jun 15;6(2):103-4. doi: 10.1186/1897-4287-6-2-103.
Abstract
摘要
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MSH6 syndrome.MSH6综合征。
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Neoadjuvant therapy in microsatellite-stable colorectal carcinoma induces concomitant loss of MSH6 and Ki-67 expression.微卫星稳定型结直肠癌的新辅助治疗可导致MSH6和Ki-67表达同时缺失。
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本文引用的文献
1
Frequency of constitutional MSH6 mutations in a consecutive series of families with clinical suspicion of HNPCC.一系列临床怀疑患有遗传性非息肉病性结直肠癌（HNPCC）的连续家族中，体质性MSH6突变的频率。
Clin Genet. 2007 Sep;72(3):230-7. doi: 10.1111/j.1399-0004.2007.00856.x.
2
Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.林奇综合征（遗传性非息肉病性结直肠癌）的诊断
J Natl Cancer Inst. 2007 Feb 21;99(4):291-9. doi: 10.1093/jnci/djk051.
3
Frequency and nature of hMSH6 germline mutations in Polish patients with colorectal, endometrial and ovarian cancers.波兰结直肠癌、子宫内膜癌和卵巢癌患者中hMSH6种系突变的频率及性质
Clin Genet. 2006 Jul;70(1):68-70. doi: 10.1111/j.1399-0004.2006.00630.x.
4
The genetics of HNPCC: application to diagnosis and screening.遗传性非息肉病性结直肠癌的遗传学：在诊断和筛查中的应用。
Crit Rev Oncol Hematol. 2006 Jun;58(3):208-20. doi: 10.1016/j.critrevonc.2005.11.001. Epub 2006 Jan 23.
5
Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German Hereditary Nonpolyposis Colorectal Cancer Consortium.与携带MLH1或MSH2突变的家族相比，27个携带致病性MSH6种系突变的家族中结直肠癌发病率较低且发病年龄较晚：德国遗传性非息肉病性结直肠癌联盟
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6
Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance.MSH6 突变导致的遗传性非息肉病性结直肠癌的癌症风险：对咨询和监测的影响。
Gastroenterology. 2004 Jul;127(1):17-25. doi: 10.1053/j.gastro.2004.03.068.
7
Eight novel MSH6 germline mutations in patients with familial and nonfamilial colorectal cancer selected by loss of protein expression in tumor tissue.通过肿瘤组织中蛋白质表达缺失筛选出的家族性和非家族性结直肠癌患者中的八个新的MSH6种系突变。
Hum Mutat. 2004 Mar;23(3):285. doi: 10.1002/humu.9217.
8
Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden.结直肠癌和子宫内膜双原发性癌患者中MLH1、MSH2和MSH6基因的突变分析：瑞典北部一项基于人群的研究
Int J Cancer. 2004 Apr 10;109(3):370-6. doi: 10.1002/ijc.11718.
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DNA repair.
J Cell Sci. 2004 Feb 1;117(Pt 4):515-7. doi: 10.1242/jcs.00952.
10
Escherichia coli as a model system to study DNA repair genes of eukaryotic organisms.
Genet Mol Res. 2003 Mar 31;2(1):77-91.
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