Escherichia coli as a model system to study DNA repair genes of eukaryotic organisms.
作者信息
Augusto-Pinto Luiz, da Silva Carlos Gustavo Regis, Lopes Débora de Oliveira, Machado-Silva Alice, Machado Carlos Renato
机构信息
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, 30161-970 Belo Horizonte, MG, Brasil.
出版信息
Genet Mol Res. 2003 Mar 31;2(1):77-91.
PMID:12917804
Abstract
The bacteria Escherichia coli has been widely employed in studies of eukaryotic DNA repair genes. Several eukaryotic genes have been cloned by functional complementation of mutant lineages of E. coli. We examined the similarities and differences among bacterial and eukaryotic DNA repair systems. Based on these data, we examined tools used for gene cloning and functional studies of DNA repair in eukaryotes, using this bacterial system as a model.
摘要
Zotero 插件