DNA双链断裂成为焦点。
DNA double-strand breaks come into focus.
作者信息
Hopfner Karl-Peter
机构信息
Center for Integrated Protein Science Munich and Munich Center for Advanced Photonics at the Gene Center, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.
出版信息
Cell. 2009 Oct 2;139(1):25-7. doi: 10.1016/j.cell.2009.09.017.
The Mre11-Rad50-Nbs1 (MRN) complex senses DNA double-strand breaks and recruits different repair pathway and checkpoint proteins to break foci. Two new studies (Williams et al., 2009; Lloyd et al., 2009) identify Nbs1 as a key factor in this process and reveal how an N-terminal protein recruitment module in Nbs1 binds to different response factors through shared phosphopeptide motifs.
Mre11-Rad50-Nbs1（MRN）复合物可感知DNA双链断裂，并将不同的修复途径和检查点蛋白募集到断裂位点。两项新的研究（Williams等人，2009年；Lloyd等人，2009年）确定Nbs1是这一过程中的关键因素，并揭示了Nbs1中的一个N端蛋白募集模块如何通过共享的磷酸肽基序与不同的反应因子结合。
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