Sohmen Daniel, Harms Joerg M, Schlünzen Frank, Wilson Daniel N
University of Munich, Germany.
Cell. 2009 Oct 2;139(1):212-212.e1. doi: 10.1016/j.cell.2009.08.009.
The translational apparatus is one of the major targets for antibiotics in the bacterial cell. Antibiotics predominantly interact with the functional centers of the ribosome, namely the messenger RNA (mRNA)-transfer RNA (tRNA) decoding region on the 30S subunit, the peptidyltransferase center on the 50S subunit, or the ribosomal exit tunnel through which the nascent polypeptide chain passes during translation. Protein synthesis can be divided into three phases: initiation, elongation, and termination/recycling.
翻译装置是细菌细胞中抗生素的主要作用靶点之一。抗生素主要与核糖体的功能中心相互作用，即30S亚基上的信使核糖核酸（mRNA）-转运核糖核酸（tRNA）解码区域、50S亚基上的肽基转移酶中心，或新生多肽链在翻译过程中穿过的核糖体出口通道。蛋白质合成可分为三个阶段：起始、延伸和终止/循环。
