核糖体药物抗性和特异性的要素。
Elements of ribosomal drug resistance and specificity.
机构信息
Department of Biochemistry, University of California, Riverside, CA 92521, USA.
出版信息
Curr Opin Struct Biol. 2012 Dec;22(6):750-8. doi: 10.1016/j.sbi.2012.07.016. Epub 2012 Sep 13.
Abstract
The structures of ribosomes in complex with inhibitors of translation have not only shed light on the interactions of antibiotics with the ribosome but also on the underlying mechanisms by which they interfere with the ribosome function. Several recent papers [1(•),2(••),3,4] have correlated the available ribosome structures with the wealth of biochemical data [5(•)]. In this review we shall focus on the lessons learned for drug specificity rather than presenting a comprehensive survey of the known structures of ribosome complexes with antibiotics.
摘要
核糖体与翻译抑制剂复合物的结构不仅揭示了抗生素与核糖体的相互作用，还揭示了它们干扰核糖体功能的潜在机制。最近的几篇论文[1(•),2(••),3,4]将现有的核糖体结构与丰富的生化数据[5(•)]相关联。在这篇综述中，我们将重点介绍药物特异性方面的经验教训，而不是全面介绍已知的抗生素与核糖体复合物的结构。
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本文引用的文献
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A new understanding of the decoding principle on the ribosome.核糖体解码原理的新认识。
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The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome.抗生素热稳定核糖体抑制蛋白通过结合核糖体亚基间桥 B2a 抑制蛋白质合成。
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