在儿科患者的毛细血管血样中测量胱抑素 C。

Measurement of cystatin C in capillary blood samples in pediatric patients.

机构信息

Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands, De Boelelaan 1117, 1081 HV, The Netherlands.

出版信息

Clin Biochem. 2010 Feb;43(3):335-7. doi: 10.1016/j.clinbiochem.2009.09.021. Epub 2009 Oct 3.

DOI:10.1016/j.clinbiochem.2009.09.021

PMID:19804772

Abstract

We assessed whether the GFR marker cystatin C can be measured reliably in capillary blood samples in children with renal disease. Cystatin C was measured in venous and capillary blood samples obtained simultaneously from 48 children, and GFR was estimated using the Filler equation. Estimated GFR based on capillary cystatin C concentrations was higher than the venous cystatin C based GFR. The limits of agreement between estimated GFR based on capillary and venous measurements exceeded +/-20% at the upper reference concentration, which hampers the clinical usefulness of capillary sampling.

摘要

我们评估了胱抑素 C 这种肾小球滤过率标志物是否能在患有肾脏疾病的儿童的毛细血管血样中可靠测量。我们同时从 48 名儿童采集静脉血和毛细血管血样，用 Filler 方程估算肾小球滤过率。基于毛细血管胱抑素 C 浓度估算的肾小球滤过率高于基于静脉胱抑素 C 的肾小球滤过率。基于毛细血管和静脉测量的估算肾小球滤过率之间的一致性界限在参考浓度上限超过 +/-20%，这限制了毛细血管采样的临床应用。