Abduljabbar M, Al Shahri A, Afifi A
Department of Pediatrics, Saudi Aramco Medical Services Organization, Eastern Province, Saudi Arabia.
J Med Screen. 2009;16(3):119-23. doi: 10.1258/jms.2009.009035.
To assess the performance of the use of umbilical cord blood for screening of primary congenital hypothyroidism in the Saudi Aramco Medical Services Organization newborn thyroid screening programme.
Umbilical cord blood total thyroxin (CB-TT4) was measured. In samples with low T4 concentrations, an additional measurement of cord blood thyroid-stimulating hormone was made.
A total of 96,015 newborn infants were screened in the period January 1990-December 2007. Twenty-six cases of primary congenital hypothyroidism, six cases of transient hypothyroidism and 13 cases of central hypothyroidism were detected. This method of screening resulted in 100% sensitivity and 98% specificity (95% CI 84-100, and 95% CI 98-98.2, respectively). However, there was a high mean recall rate of 1.9%.
The use of CB-TT4 is a valid screening strategy for primary congenital hypothyroidism. It meets the metabolic screening demands of early discharge policy and guarantees screening all newborns delivered in the hospital.
评估在沙特阿美石油公司医疗服务组织新生儿甲状腺筛查项目中，使用脐带血筛查原发性先天性甲状腺功能减退症的效果。
检测脐带血总甲状腺素（CB-TT4）。对于T4浓度低的样本，额外检测脐带血促甲状腺激素。
在1990年1月至2007年12月期间，共筛查了96,015名新生儿。检测出26例原发性先天性甲状腺功能减退症、6例暂时性甲状腺功能减退症和13例中枢性甲状腺功能减退症。这种筛查方法的敏感性为100%，特异性为98%（95%可信区间分别为84 - 100和98 - 98.2）。然而，平均召回率较高，为1.9%。
使用CB-TT4是原发性先天性甲状腺功能减退症的一种有效筛查策略。它满足了早期出院政策的代谢筛查需求，并确保对在医院分娩的所有新生儿进行筛查。
