Carr L A, Conway P M, Voogt J L
Brain Res. 1977 Sep 16;133(2):305-14. doi: 10.1016/0006-8993(77)90766-1.
Release of prolactin from the anterior pituitary can be induced by a variety of neuronal and hormonal stimuli, including suckling and estrogen. To determine whether noradrenergic neurons in the central nervous system mediate the response to either of these stimuli, norepinephrine synthesis was inhibited by diethyldithiocarbamate (DDC; 50 mg/kg). When administered to suckled, lactating rats, DDC had no effect on suckling-induced increase in plasma prolactin. The drug also had no effect on prolactin levels in ovariectomized rats. However, when DDC was administered to ovariectomized rats treated with estrogen to increase plasma prolactin levels, there was a fall in plasma prolactin levels which correlated with a decrease in hypothalamic norepinephrine synthesis. It is proposed that estrogen increases noradrenergic neuron activity which in turn increases prolactin release from the pituitary.
来自腺垂体的催乳素释放可由多种神经和激素刺激诱导，包括哺乳和雌激素。为了确定中枢神经系统中的去甲肾上腺素能神经元是否介导对这些刺激之一的反应，用二乙基二硫代氨基甲酸盐（DDC；50mg/kg）抑制去甲肾上腺素的合成。当给予哺乳的泌乳大鼠时，DDC对哺乳诱导的血浆催乳素升高没有影响。该药物对去卵巢大鼠的催乳素水平也没有影响。然而，当将DDC给予用雌激素治疗以增加血浆催乳素水平的去卵巢大鼠时，血浆催乳素水平下降，这与下丘脑去甲肾上腺素合成减少相关。有人提出，雌激素增加去甲肾上腺素能神经元活性，进而增加垂体催乳素的释放。
