Mena F, Enjalbert A, Carbonell L, Priam M, Kordan C
Endocrinology. 1976 Aug;99(2):445-51. doi: 10.1210/endo-99-2-445.
In lactating rats that were separated from their pups for 8 hours, suckling induced a rapid rise in plasma prolactin levels. Correlatively, it induced a depletion in dopamine (DA) and serotonin (5-HT) Concentrations within the hypothalamus as early as 5 min after the onset of suckling. This depletion lasted as long as the stimulus was maintained. A parallel increase in the level of the metabolite of 5-HT, 5-hydroxyindolacetic acid (5-HIAA), was observed. Under these conditons, the ratio of 5-HIAA/5-HT is augmented. This ratio is a good index of turnover of the transmitter. Suckling affected neither the content of noradrenaline (NA) in the hypothalamus nor the levels of any amine tested in the cerebral cortex. When pups were separated from their mother for 24 hours, suckling no longer resulted in changes in either plasma prolactin levels or hypothalamic DA, 5-HT, or 5-HIAA concentrations. We have concluded that the activation of a discrete system of 5-HT containing neurons is associated with the triggering effect of suckling on prolactin release.
在与幼崽分离8小时的哺乳期大鼠中，哺乳会导致血浆催乳素水平迅速升高。相应地，早在哺乳开始后5分钟，它就会导致下丘脑内多巴胺（DA）和5-羟色胺（5-HT）浓度降低。只要刺激持续，这种降低就会持续。观察到5-HT代谢物5-羟吲哚乙酸（5-HIAA）水平同时升高。在这些条件下，5-HIAA/5-HT的比值会增加。该比值是递质周转的良好指标。哺乳既不影响下丘脑去甲肾上腺素（NA）的含量，也不影响大脑皮层中所检测的任何胺类水平。当幼崽与母亲分离24小时后，哺乳不再导致血浆催乳素水平或下丘脑DA、5-HT或5-HIAA浓度发生变化。我们得出结论，含5-HT神经元的离散系统的激活与哺乳对催乳素释放的触发作用有关。
