Acute Psychiatric Ward and Research Unit, Sha'ar Menashe Mental Health Center, Mobile Post Hefer 38814, Hadera, Israel.
Expert Rev Pharmacoecon Outcomes Res. 2003 Apr;3(2):189-99. doi: 10.1586/14737167.3.2.189.
Although health-related quality of life is an amorphous and heterogeneous concept, it has become an important outcome measure in the treatment of psychiatric disorders. This review illustrates the negative effects of distress/clinical factors (psychological distress, anxiety, depressive and negative symptoms) on quality of life of psychiatric patients. Contradictory findings have been reported regarding the relationship of positive symptoms, cognitive deficits and insight with quality of life scores among schizophrenia patients. Increasing evidence suggests that psychosocial or stress process related rather than clinical factors more accurately predict quality of life. The authors suggest that the impact of distress/clinical factors on subjective quality of life of mentally disordered patients is experienced through psychosocial factors. Limitations in current knowledge in this area are identified and suggestions for future research are provided.
虽然与健康相关的生活质量是一个模糊且多样的概念，但它已成为治疗精神障碍的重要结果衡量标准。本综述说明了困扰/临床因素（心理困扰、焦虑、抑郁和阴性症状）对精神疾病患者生活质量的负面影响。在精神分裂症患者的阳性症状、认知缺陷和洞察力与生活质量评分之间的关系方面，已经报告了相互矛盾的发现。越来越多的证据表明，与心理社会或压力过程相关的因素而不是临床因素更能准确预测生活质量。作者认为，困扰/临床因素对精神障碍患者主观生活质量的影响是通过心理社会因素来体验的。确定了该领域当前知识的局限性，并提出了未来研究的建议。
