同源结构域的结构及其功能意义。
The structure of the homeodomain and its functional implications.
作者信息
Gehring W J, Müller M, Affolter M, Percival-Smith A, Billeter M, Qian Y Q, Otting G, Wüthrich K
机构信息
University of Basel, Switzerland.
出版信息
Trends Genet. 1990 Oct;6(10):323-9. doi: 10.1016/0168-9525(90)90253-3.
PMID:1980756
Abstract
The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.
摘要
通过核磁共振光谱法确定的同源异型结构域的三维结构显示存在一种螺旋-转角-螺旋基序，类似于在原核基因调节蛋白中发现的基序。分离出的同源异型结构域以高亲和力与特定DNA序列结合。因此，结构-功能关系在进化过程中高度保守。
Zotero 插件