Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195, USA.
Cell Metab. 2009 Oct;10(4):241-2. doi: 10.1016/j.cmet.2009.09.003.
Obesity-induced inflammation causes cellular resistance to both insulin and leptin. In this issue, Brüning and colleagues (Kleinridders et al., 2009) add to growing evidence that this response occurs in the hypothalamus, as well as in peripheral tissues, which helps to explain how high-fat feeding induces a gradual increase in defended body weight.
肥胖引起的炎症会导致细胞对胰岛素和瘦素产生抵抗。在本期杂志中，Brüning 及其同事（Kleinridders 等人，2009）的研究进一步证实，这种反应不仅发生在外周组织，也发生在下丘脑，这有助于解释高脂喂养如何逐渐导致体重增加。
