Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Cell Metab. 2009 Oct;10(4):247-8. doi: 10.1016/j.cmet.2009.09.004.
Several studies indicate that reduced TOR signaling underlies life span extension by dietary restriction. Recently, Zid et al. (Zid et al., 2009) linked the benefits of dietary restriction in flies to increased levels of the downstream TOR target 4E-BP1 and corresponding changes in the relative translation rates of classes of mRNAs.
几项研究表明，TOR 信号的降低是饮食限制延长寿命的基础。最近，Zid 等人（Zid 等人，2009 年）将饮食限制对果蝇的益处与下游 TOR 靶标 4E-BP1 水平的升高联系起来，并相应地改变了 mRNA 类别的相对翻译率。
