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The tumultuous journey of nesiritide: past, present, and future.

作者信息

Burnett John C, Korinek Josef

出版信息

Circ Heart Fail. 2008 May;1(1):6-8. doi: 10.1161/CIRCHEARTFAILURE.108.776294.

DOI:10.1161/CIRCHEARTFAILURE.108.776294
PMID:19808264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4684180/
Abstract
摘要

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The tumultuous journey of nesiritide: past, present, and future.奈西立肽的跌宕历程：过去、现在与未来。
Circ Heart Fail. 2008 May;1(1):6-8. doi: 10.1161/CIRCHEARTFAILURE.108.776294.
2
Nesiritide therapy for decompensated heart failure.
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Nesiritide for the treatment of congestive heart failure.奈西立肽用于治疗充血性心力衰竭。
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4
Nesiritide: harmful or harmless?奈西立肽：有害还是无害？
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5
Nesiritide therapy for acute heart failure.
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Controversy and conflict in the treatment of acute decompensated heart failure: nesiritide as evidence-based treatment.急性失代偿性心力衰竭治疗中的争议与冲突：奈西立肽作为循证治疗方法
Pharmacotherapy. 2007 May;27(5):619-25. doi: 10.1592/phco.27.5.619.
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Nesiritide: the latest drug for treating heart failure.
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Efficacy and safety of nesiritide in patients with acute decompensated heart failure.奈西立肽治疗急性失代偿性心力衰竭患者的疗效与安全性。
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Natriuretic peptide pathways in heart failure: further therapeutic possibilities.心力衰竭中的利钠肽途径：更多的治疗可能性。
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Impaired sinoatrial node function and increased susceptibility to atrial fibrillation in mice lacking natriuretic peptide receptor C.缺乏利钠肽受体C的小鼠窦房结功能受损且对心房颤动的易感性增加。
J Physiol. 2015 Mar 1;593(5):1127-46. doi: 10.1113/jphysiol.2014.283135. Epub 2015 Jan 12.
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Rationale and design of a randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy of B-type natriuretic peptide for the preservation of left ventricular function after anterior myocardial infarction.一项随机、双盲、安慰剂对照临床试验的原理和设计，旨在评估 B 型利钠肽在前壁心肌梗死后保护左心室功能的疗效。
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Advances in the epidemiology of heart failure and left ventricular remodeling.心力衰竭与左心室重构的流行病学进展
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CD-NP: an innovative designer natriuretic peptide activator of particulate guanylyl cyclase receptors for cardiorenal disease.CD-NP：一种用于治疗心肾疾病的新型设计型利钠肽激活剂，可激活颗粒型鸟苷酸环化酶受体
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Pharmacodynamics of a novel designer natriuretic peptide, CD-NP, in a first-in-human clinical trial in healthy subjects.新型设计型利钠肽CD-NP在健康受试者首次人体临床试验中的药效学
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Designer natriuretic peptides.设计型利钠肽
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Modulation of cGMP in heart failure: a new therapeutic paradigm.心力衰竭中cGMP的调节：一种新的治疗模式。
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Nesiritide in acute decompensated heart failure: current status and future perspectives.奈西立肽治疗急性失代偿性心力衰竭：现状与未来展望。
Rev Cardiovasc Med. 2008 Summer;9(3):151-8.
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Insights into natriuretic peptides in heart failure: an update.心力衰竭中利钠肽的研究进展：最新综述
Curr Heart Fail Rep. 2008 Jun;5(2):97-104. doi: 10.1007/s11897-008-0016-y.

本文引用的文献

1
Safety and efficacy of outpatient nesiritide in patients with advanced heart failure: results of the Second Follow-Up Serial Infusions of Nesiritide (FUSION II) trial.奈西立肽门诊治疗晚期心力衰竭患者的安全性和有效性：奈西立肽第二次随访连续输注（FUSION II）试验结果
Circ Heart Fail. 2008 May;1(1):9-16. doi: 10.1161/CIRCHEARTFAILURE.108.767483.
2
Impact of nesiritide on renal function in patients with acute decompensated heart failure and pre-existing renal dysfunction a randomized, double-blind, placebo-controlled clinical trial.奈西立肽对急性失代偿性心力衰竭合并肾功能不全患者肾功能的影响：一项随机、双盲、安慰剂对照临床试验
J Am Coll Cardiol. 2007 Nov 6;50(19):1835-40. doi: 10.1016/j.jacc.2007.03.071. Epub 2007 Oct 23.
3
Effect of nesiritide on renal function in patients admitted for decompensated heart failure.奈西立肽对因失代偿性心力衰竭入院患者肾功能的影响。
QJM. 2007 Nov;100(11):699-706. doi: 10.1093/qjmed/hcm089.
4
Low dose nesiritide and the preservation of renal function in patients with renal dysfunction undergoing cardiopulmonary-bypass surgery: a double-blind placebo-controlled pilot study.低剂量奈西立肽与体外循环手术中肾功能不全患者肾功能的保护：一项双盲安慰剂对照的初步研究。
Circulation. 2007 Sep 11;116(11 Suppl):I134-8. doi: 10.1161/CIRCULATIONAHA.106.697250.
5
The safety of intravenous diuretics alone versus diuretics plus parenteral vasoactive therapies in hospitalized patients with acutely decompensated heart failure: a propensity score and instrumental variable analysis using the Acutely Decompensated Heart Failure National Registry (ADHERE) database.急性失代偿性心力衰竭住院患者中，单纯静脉利尿剂与利尿剂加肠外血管活性治疗的安全性：一项使用急性失代偿性心力衰竭国家注册（ADHERE）数据库的倾向评分和工具变量分析。
Am Heart J. 2007 Aug;154(2):267-77. doi: 10.1016/j.ahj.2007.04.033.
6
Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various molecular forms of human B-type natriuretic peptide.人B型利钠肽各种分子形式的免疫反应性及环磷酸鸟苷激活作用
Hypertension. 2007 May;49(5):1114-9. doi: 10.1161/HYPERTENSIONAHA.106.081083. Epub 2007 Mar 19.
7
Evidence for functional heterogeneity of circulating B-type natriuretic peptide.循环B型利钠肽功能异质性的证据。
J Am Coll Cardiol. 2007 Mar 13;49(10):1071-8. doi: 10.1016/j.jacc.2006.10.063. Epub 2007 Feb 26.
8
Effects of perioperative nesiritide in patients with left ventricular dysfunction undergoing cardiac surgery:the NAPA Trial.围手术期奈西立肽对接受心脏手术的左心室功能不全患者的影响：NAPA试验
J Am Coll Cardiol. 2007 Feb 13;49(6):716-26. doi: 10.1016/j.jacc.2006.10.048. Epub 2006 Dec 11.
9
Renal hyporesponsiveness to atrial natriuretic peptide in congestive heart failure results from reduced atrial natriuretic peptide receptor concentrations.充血性心力衰竭时肾脏对心房利钠肽反应性降低是由于心房利钠肽受体浓度降低所致。
Am J Physiol Renal Physiol. 2007 May;292(5):F1636-44. doi: 10.1152/ajprenal.00418.2006. Epub 2007 Jan 30.
10
Short and long-term mortality with nesiritide.奈西立肽的短期和长期死亡率
Am Heart J. 2006 Dec;152(6):1084-90. doi: 10.1016/j.ahj.2006.07.002.