Shingleton H M, Lawrence W D, Gore H
Cancer. 1977 Sep;40(3):1112-21. doi: 10.1002/1097-0142(197709)40:3<1112::aid-cncr2820400321>3.0.co;2-m.
Three cases of cervical carcinoma with an adenoid cystic pattern were studied by light and electron microscopy. All were found to be compatible with the histologic picture of adenoid cystic carcinoma in other body sites. Although there was some variability in the pattern among the tumors, areas of each exhibited a cribriform appearance characterized by small cells with sparse cytoplasm arranged around cystic gland-like lumina. Only one tumor displayed cylindromatous formations similar to those described by Billroth. Two of the tumors were associated with foci of squamous cell carcinoma while the third contained areas suggestive of such a component. Electron microscopic examination showed varied morphology of the cysts, manifested by true glandlike lumina, extracellular spaces containing replicated basement membrane or enclosed stroma. In view of the observed diversity in the light and electron microscopic morphology of adenoid cystic carcinomas of the cervix, it is apparent that this tumor is not a distinct histologic entity. Accordingly, it is recommended that the terminology "cervical carcinoma with adenoid cystic pattern" be utilized.
对3例具有腺样囊性结构的宫颈癌进行了光镜和电镜研究。所有病例均发现与其他身体部位腺样囊性癌的组织学表现相符。尽管肿瘤之间的结构存在一定差异，但每个肿瘤区域均呈现筛状外观，其特征为围绕囊性腺样管腔排列的细胞质稀少的小细胞。仅1例肿瘤显示出与比尔罗特所描述的类似的圆柱瘤样结构。其中2例肿瘤伴有鳞状细胞癌灶，而第3例含有提示存在该成分的区域。电镜检查显示囊肿形态多样，表现为真正的腺样管腔、含有复制基底膜或包绕间质的细胞外间隙。鉴于观察到的宫颈腺样囊性癌光镜和电镜形态的多样性，显然该肿瘤并非一种独特的组织学实体。因此，建议采用“具有腺样囊性结构的宫颈癌”这一术语。
