Lefrancq T, de Muret A, Michalak S, Lhuintre Y, Fetissof F
Laboratoire d'Anatomie Pathologique, Hôpital Bretonneau, Tours.
Ann Pathol. 1997 Jul;17(3):196-9.
Adenoid basal carcinoma and adenoid cystic carcinoma are rare primary cervical neoplasms occurring in postmenopausal women. They are generally regarded as distinct entities on the basis of their distinctive morphology and a different biological behaviour. Although the separation of these two entities is still mandatory, some rare complex cases may show overlapping pathological features and are difficult to classify. We report a case of composite cervical tumor with both types of carcinoma, an in situ epidermoid carcinoma and a hitherto undescribed clear cell component, each with a different morphology and immunophenotype. The adenoid basal component is mainly immunoreactive for cytokeratin KL1. The adenoid cystic component is strongly stained for smooth muscle actin and is associated with a hyaline stroma immunostained for collagen IV.
腺样基底癌和腺样囊性癌是发生于绝经后女性的罕见原发性宫颈肿瘤。基于其独特的形态学和不同的生物学行为，它们通常被视为不同的实体。尽管将这两种实体区分开来仍然是必要的，但一些罕见的复杂病例可能表现出重叠的病理特征，难以分类。我们报告一例复合性宫颈肿瘤，包含这两种类型的癌、原位表皮样癌和一种迄今未描述的透明细胞成分，每种成分都有不同的形态学和免疫表型。腺样基底成分主要对细胞角蛋白KL1呈免疫反应性。腺样囊性成分平滑肌肌动蛋白染色强阳性，并与经IV型胶原免疫染色的透明样间质相关。
