Otani Lila, Ninomiya Toshio, Murakami Megumi, Osajima Katsuhiro, Kato Hisanori, Murakami Tetsuo
Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University, Nara, Japan.
Biosci Biotechnol Biochem. 2009 Oct;73(10):2203-9. doi: 10.1271/bbb.90311. Epub 2009 Oct 7.
An enzymatic hydrolysate of sardine protein (sardine peptide, SP) derived from sardine muscle possesses angiotensin I-converting enzyme (ACE) inhibitory activity. In the present study, we investigated the effect of SP on the blood glucose levels in stroke-prone spontaneously hypertensive rats (SHRSPs). Ten-week-old SHRSPs were assigned to three groups. The control group was given tap water for 4 weeks, while the experimental groups were given water containing SP (1 g/kg/d) or an ACE inhibitor, captopril (8 mg/kg/d). Treatment with SP and captopril decreased ACE activity in the kidney, aorta, and mesentery. There were no differences in fasting blood glucose levels among the three groups, whereas SP and captopril administration significantly suppressed the increase in blood glucose after glucose loading in the control SHRSPs. No difference was observed in plasma insulin levels among the three groups. Thus treatment with captopril and ACE-inhibitory sardine peptides ameliorated the glucose tolerance of this rat strain.
源自沙丁鱼肌肉的沙丁鱼蛋白酶解物（沙丁鱼肽，SP）具有血管紧张素I转换酶（ACE）抑制活性。在本研究中，我们调查了SP对易中风自发性高血压大鼠（SHRSPs）血糖水平的影响。将10周龄的SHRSPs分为三组。对照组给予自来水4周，而实验组给予含SP（1 g/kg/d）的水或ACE抑制剂卡托普利（8 mg/kg/d）。用SP和卡托普利治疗可降低肾脏、主动脉和肠系膜中的ACE活性。三组之间的空腹血糖水平没有差异，而给予SP和卡托普利可显著抑制对照SHRSPs葡萄糖负荷后血糖的升高。三组之间的血浆胰岛素水平未观察到差异。因此，用卡托普利和具有ACE抑制作用的沙丁鱼肽治疗可改善该大鼠品系的葡萄糖耐量。
