Mohr E, Mann U M, Chase T N
Royal Ottawa Hospital, Neuropsychology Service, Ontario, Canada.
Psychiatr J Univ Ott. 1990 Nov;15(4):203-6.
Alzheimer's disease, which accounts for the majority of all dementing disorders, presents with a wide spectrum of demographic, neuropsychological, pathological and biochemical characteristics. It has become increasingly clear that Alzheimer's disease is indeed heterogeneous and lack of success in symptomatic treatment may be in part related to this. In an attempt to evaluate the utility of possible subgrouping schemas, we reviewed current criteria used to subclassify patients with Alzheimer's disease. Results suggest that although treatment attempts may have to take a more individualized approach, most current subgrouping concepts will probably have limited therapeutic utility.
阿尔茨海默病占所有痴呆症的大多数，具有广泛的人口统计学、神经心理学、病理学和生化特征。越来越明显的是，阿尔茨海默病确实具有异质性，而对症治疗的失败可能部分与此有关。为了评估可能的亚组分类方案的效用，我们回顾了目前用于对阿尔茨海默病患者进行亚分类的标准。结果表明，尽管治疗尝试可能需要采取更个性化的方法，但目前大多数亚组分类概念的治疗效用可能有限。
