St Sauver Jennifer L, Jacobsen Steven J
Curr Prostate Rep. 2008 May 1;6(2):67-73. doi: 10.1007/s11918-008-0011-5.
Inflammation is a common finding in histologic prostate specimens obtained from aging men, and accumulating data suggest that inflammation may play an important role in the development of benign prostatic hyperplasia (BPH), and the development and progression of lower urinary tract symptoms (LUTS). Inflammatory processes may contribute to prostatic enlargement directly through stimulation of prostate growth, or, alternatively, through decreasing prostatic apoptosis. Additionally, inflammatory processes may impact other components of the urogenital tract, such as the bladder, and contribute to the LUTS that may be experienced both in the presence and in the absence of prostate enlargement. Current research therefore offers clues about converging inflammatory pathways which may be targeted to improve treatment of BPH and/or LUTS as well as identifying potential targets for prevention of these syndromes.
炎症是从老年男性获取的前列腺组织学标本中的常见表现，越来越多的数据表明，炎症可能在良性前列腺增生（BPH）的发生以及下尿路症状（LUTS）的发生和进展中起重要作用。炎症过程可能通过刺激前列腺生长直接导致前列腺肿大，或者通过减少前列腺细胞凋亡来实现。此外，炎症过程可能影响泌尿生殖道的其他组成部分，如膀胱，并导致无论前列腺是否肿大都可能出现的LUTS。因此，当前的研究为汇聚的炎症途径提供了线索，这些途径可能成为改善BPH和/或LUTS治疗的靶点，同时也有助于确定预防这些综合征的潜在靶点。
